UnknownhiI hope to god notMost likely not, as the Flood was destroyed at the end of Halo 3 t is unlikely.
The gravemind is destroyed so all Floods are dead or hidden and will not appear.
Actually only the Flood from Delta Halo, Earth, and the Ark were killed in the firing of Alpha Halo (B). And they came from another Galaxy, so they might as well be in Halo: 4. 18.104.22.168 06:22, September 19, 2011 (UTC)
Only a small portion of the mass of flood was destroyed. But the remaining status of the others is "secure" at the moment anyway. There is a chance we'll be hearing that good ol' flood theme again!